Tagged: B cells

• Affinity Maturation

  A comprehensive guide to how the immune system evolves increasingly potent antibodies through iterative cycles of mutation and selection in germinal centers.

• Immunoglobulin Gene Recombination

  A comprehensive guide to how B cells assemble unique antibody genes through V(D)J recombination at the immunoglobulin heavy and light chain loci.

• Germinal Centers

  A comprehensive guide to the specialized microanatomical structures where B cells undergo affinity maturation, class switching, and memory formation during T-dependent immune responses.

• Somatic Hypermutation

  A comprehensive guide to how B cells evolve higher-affinity antibodies through targeted mutation in germinal centers, including the molecular mechanisms, regulation, and clinical significance.

• B Cell Development

  A comprehensive guide to B lymphocyte development, from hematopoietic stem cells in the bone marrow through mature B cell subsets in the periphery.